Documentation recommendations reproduced/adapted from: Mullin S, Beckwith. Complete Patient Safety Net (PSN) Report. Document all procedures in the medical record. Apply warm packs for 15-20 minutes at day. Do not give protamine when bleeding occurs without prior heparin use. Heparin Antidote Protamine Sulphate Watch on Abstract: Heparin antidote is protamine sulphate. for 15-20 minutes at least four times a day least four times a. Administration requires a specialized care setting as vasopressors and resuscitation equipment should be immediately available in case of a severe reaction. The goal of antidote administration is to reverse the action of the extravasated agent, interfere with the process of cell destruction, prevent tissue necrosis, or limit the extent of tissue damage. A patient receiving heparin therapy will need to be monitored for bleeding. Protamine sulfate is a basic protein derived from fish sperm that binds to heparin to form a stable salt. of heparin Dose of protamine for each 100 units of heparin administered Immediate 1mg (or 25mg fixed dose) 30 minutes 2 hrs 0.5mg (or 10mg fixed dose) >2 hrs 0. Carefully consider the risks and benefits of use in patients with any of these risk factors. Protamine sulfate is a medication used to reverse and counteract the effects of heparin. Fish hypersensitivity, vasectomy, severe left ventricular dysfunction, and abnormal preoperative pulmonary hemodynamics may also be risk factors. Risk factors for these events include high doses or overdose, rapid IV administration, previous exposure, repeated doses, and current or previous use of protamine-containing drugs (e.g., NPH insulin, protamine zinc insulin, and certain beta-blockers). Protamine administration has a risk of serious hypersensitivity reactions or anaphylaxis manifesting as severe hypotension, cardiovascular collapse, pulmonary edema, pulmonary vasoconstriction, and pulmonary hypertension. Fish hypersensitivity, requires a specialized care setting, risk of serious hypersensitivity reactions or anaphylaxis, ventricular dysfunction
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